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Bioavailability of Drugs
- Bioavailability refers to the amount of administered drug reaching circulation.
- Intravenous administration has 100% bioavailability, while other routes, like oral, have less due to factors like first-pass metabolism.
Drug Ionization and Absorption
- A drug's pH and the environment's pH affect its ionization and absorption.
- Non-ionized drugs, being lipophilic, cross cell membranes easier, while ionized drugs struggle.
Gastric Motility and Emptying
- Gastric motility and emptying affect drug absorption in the GI tract.
- These factors change with age, food intake, and other variables.