The Stem Cell Podcast

Ep. 88: “Homing Neural Stem Cells” Featuring Dr. Shawn Hingtgen

Mar 28, 2017
Dr. Shawn Hingtgen, a molecular pharmaceutics researcher using imaging and stem-cell delivery against brain cancer, and Dr. Matthew G. Ewend, a neurosurgeon tackling glioblastoma surgically and translationally. They discuss neural stem cells that home to invasive brain tumors. Topics include tumor-homing signals, rapid patient-specific reprogramming, preclinical homing and kill data, safety switches, and steps toward clinical translation.
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INSIGHT

CXCR4 SDF Axis Drives Stem Cell Tumor Tropism

  • The CXCR4–SDF signaling axis is a key chemoattractant guiding stem cells to tumors.
  • Shawn Hingtgen notes tumors emit SDF and stem cells bearing CXCR4 crawl toward those gradients to infiltrate lesions.
ADVICE

Use Autologous Cells To Reduce Rejection Risks

  • Make autologous cells to avoid rejection and steroids and to maximize persistence for homing and drug delivery.
  • Hingtgen and Matthew G. Ewend chose patient-derived skin→neural stem cells to create personalized, fast-to-produce therapies.
INSIGHT

Glioblastoma Survival Has Hardly Improved

  • Median survival for newly diagnosed glioblastoma improved only modestly over decades and remains ~15 months, underscoring need for radical new therapies.
  • Matthew G. Ewend contrasts historical ~12 months to current ~15 months and calls for bigger treatment advances.
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