
The Interview Karim Beguir, co-founder of InstaDeep: People are too gloomy about AI
Mar 11, 2026
Karim Beguir, co-founder and CEO of InstaDeep who built Africa’s largest AI firm, speaks about building powerful AI from Tunisia. He recounts starting with two laptops and early research wins. He discusses teaming with BioNTech on variant screening, Project Tatooine for training African tech talent, and why AI can create local opportunity rather than just displace jobs.
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Childhood Duty Shaped A Tech Mission
- Karim Beguir grew up in a remote Tunisian desert town where his father was the local doctor and instilled a duty to give back.
- That upbringing shaped Karim's moral focus on putting humans first and later guided his career choices toward societal benefit.
Two Laptops And Bootstrap Grit
- InstaDeep started in 2014 with two laptops, $2,000 and no clear business plan, relying on persistence and a strong co-founder relationship.
- Karim and co-founder Zora Slim worked long hours, took zero salary for years, and focused on learning and experimentation to grow the company.
Publishing Research Became A Growth Lever
- Publishing their reinforcement learning research rather than patenting it amplified InstaDeep's visibility and attracted talent and business.
- The open-science decision turned a technical paper into hiring signals and commercial opportunities for the startup.

