In May of 1527, 20,000 mutinous soldiers of Charles V of the Holy Roman Empire descended on Rome. What would follow was the absolute devastation of the city and its population, the gutting of the power of the Papacy, and the end of the High Renaissance era.
Sources
Medievalists.net: https://www.medievalists.net/2022/06/sack-rome-1527/
Smart History: https://smarthistory.org/sack-of-rome/
Wikipedia: https://en.wikipedia.org/wiki/Sack_of_Rome_(1527)
Image: https://commons.wikimedia.org/wiki/File:The_Sack_of_Rome.jpg
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