
What's Your Problem? The Killer We Refused to See
Feb 19, 2026
Tom Levenson, MIT science writing professor and author of So Very Small, traces the long road from Leeuwenhoek’s microscopes to Pasteur and Koch. He tells why early worldviews hid microbes’ role in disease. Stories include Semmelweis’s handwashing crisis, the rise of vaccines and antibiotics, and modern threats like resistance and denial.
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Worldviews Block New Scientific Theories
- Scientific change needs both a compelling problem and a coherent alternative theory to replace the old worldview.
- A dominant worldview can blind people to obvious evidence, delaying breakthroughs for generations.
A Fad Hid A Major Discovery
- Microscopy became a short-lived social fad after Hooke and Leuwenhoek, so interest in microbes faded.
- Treating microbes as mere curiosities made it hard to see them as agents of deadly disease.
Semmelweis And The Handwashing Discovery
- Ignaz Semmelweis noticed doctors who did autopsies then delivered babies had far higher maternal death rates.
- He required handwashing with chlorine and the death rate dropped, but colleagues rejected his findings and he was ostracized.

