
Science Fictions Episode 40: Addiction
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Jun 11, 2024 Delving into addiction, the hosts discuss varied interpretations and definitions, exploring behavioral addictions. They touch on historical cases and the evolution of addiction perceptions, from moral to recognized disorders. The conversation also covers addiction research breakthroughs, misconceptions, and complexities like tolerance and dependence.
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Dopamine: Wanting More Than Pleasure
- Dopamine relates to motivation and 'wanting' more than raw pleasure or 'liking.'
- Addiction research focuses on altered motivation pathways, not a simple pleasure chemical.
Human Addiction Needs Self-Reported Loss Of Control
- In humans, addiction definitions include subjective reports of loss of control and inability to quit despite harm.
- Self-reported desire to stop but failure to do so is central to many clinical views of addiction.
Bad Evidence Drove Big Opioid Claims
- The '99% non-addictive' claim about OxyContin traced back to a single 1980 letter, not robust evidence.
- That letter influenced prescribing practices despite being weak and anecdotal.
