84. The Science of Biohacking: Peptides, Biological Age, and Cellular Optimization with Dr. Neil Paulvin

Biohacking promises longer life, sharper cognition, and faster recovery—but which strategies are actually supported by science? In this episode, Dr. Greg Jones sits down with Dr. Neil Paulvin, a New York–based, board-certified physician specializing in longevity and regenerative medicine, to separate evidence-based optimization from internet hype.

Known as “the peptide doc,” Dr. Paulvin explains why popular biological age tests often lack consistency and why functional markers—such as sleep quality, grip strength, visceral fat, and cardiovascular metrics—offer a clearer picture of long-term health. The discussion breaks down the “Core Four” lifestyle pillars for longevity, with sleep highlighted as the single most powerful driver of metabolic, hormonal, and cognitive resilience.

They also explore peptide therapy, including BPC-157 for gut health and inflammation, the Wolverine Stack for injury repair, Tesamorelin for visceral fat, and emerging mitochondrial peptides shaping the future of cellular medicine. Dr. Paulvin explains why AI tools like ChatGPT are not yet capable of replacing clinical judgment and shares insights into what’s coming next in longevity science.

Whether you’re new to biohacking or refining an advanced health optimization protocol, this episode delivers a grounded, clinically informed roadmap to improving biological age, cellular health, and performance.

📌 About Dr. Neil Paulvin

Dr. Neil Paulvin, DO, is a multiple board-certified physician with certifications in Family Medicine, Osteopathic Manipulation, and Anti-Aging and Regenerative Medicine. His Manhattan-based practice integrates conventional and functional medicine to help executives, elite athletes, and high performers optimize recovery, longevity, and resilience.

He is a recognized expert in peptide therapy, mitochondrial health, bioidentical hormones, sports medicine, and the gut–brain axis. Dr. Paulvin has spoken at the Peptide Summit and Biohacking Congress and has been featured in SHAPE, Bustle, the NY Post, and numerous national podcasts.

📌Learn more about Dr. Neil Paulvin

Website: https://doctorpaulvin.comInstagram: https://www.instagram.com/drpaulvinLinkedIn: https://www.linkedin.com/in/neil-paulvin-a437021a

📌Connect with Dr. Greg Jones

Instagram: @doctorjones_doctorjonesEnovative Wellness Center: https://enovativewellness.com/Book Dr. Jones to speak at your next event: https://www.drjonesnmd.com/

📣 Subscribe + Follow

📺 YouTube: https://www.youtube.com/@DrJonesNMDTV🎧 Spotify: https://open.spotify.com/show/2QrMGwCIGo1kjdezfCyYDK

🔗 Want to learn more? Check these resources:

• NIH – Mitochondria & Health:https://www.nih.gov/news-events/nih-research-matters/mitochondria-health 

• Peptide Therapeutics & Clinical Applications:https://www.mdpi.com/1422-0067/26/11/5131 

• NIH – Biological Aging & Biomarkers (NIA):https://www.nia.nih.gov/news/topics/biomarkers 

🔬 Chapters

Welcome and introduction (00:00 - 06:31)

Biological age testing limitations (06:31 - 07:46)

Better longevity markers (07:46 - 10:02)

The “Core Four” for health span (10:02 - 11:55)

Sleep as the top longevity driver (11:55 - 13:21)

BPC-157 and gut healing (13:21 - 15:04)

Peptides and cancer myths (15:04 - 18:27)

The Wolverine Stack (18:27 - 23:15)

Visceral fat and Tesamorelin (23:15 - 25:31)

Risks of DIY injections (25:31 - 29:55)

Cerebrolysin and brain repair (29:55 - 32:42)

AI in medicine (32:42 - 37:13)

Future peptides (37:13 - 42:14)

Closing thoughts (42:14 - 43:37)