Everyone’s Taking GLP-1s… Here’s What They’re Not Telling You With Zeke Samples

Jan 27, 2026

17:16

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GLP-1s are in every medical conversation right now. In this episode, I slow the conversation down and ask a harder question: what are we actually trading for rapid weight loss? I sat down with Zeke Samples to examine why so many patients are drawn to appetite suppression and quick fixes.

We explored what doesn’t always make it into the exam room conversation and the downstream effects of relying on pharmacology without building sustainable habits. We also discussed the clinical tension many physicians feel, wanting to help patients see results while knowing that muscle preservation, metabolic flexibility, and resilience matter far more than the number on the scale.

We talked about reducing friction through stress regulation and simple nutritional guidelines that patients can maintain. Zeke shared a framework that prioritizes consistency over intensity and behavior change over suppression. If you’re a physician looking to improve outcomes without sacrificing long-term health, this one is for you!

“Metabolism 101: You're either a fat burner, or you're a sugar burner.” ~ Zeke Samples

In This Episode:

- Side effects of GLP-1 medications

- Alternatives to GLP-1s for sustainable weight loss

- Zeke’s training and nutrition habits

- Common mistakes people make when losing weight

- Health and wellness book recommendations

Mentioned in the Episode:

Zeke Samples’ book, The Sustainable Edge: https://amzn.eu/d/2fGs0HD

Connect with Zeke Samples:

LinkedIn: https://www.linkedin.com/in/zeke-samples-8764b934

Website: https://zekesamples.com/