The Optispan Podcast with Matt Kaeberlein

Everything I do for Healthspan (and why I skip THESE Supplements)

60 snips
Jan 10, 2026
Dive into a personal health journey that covers essential lifestyle pillars: Eat, Move, Sleep, and Connect. Discover the curated supplements for longevity while learning about the ones to skip and why. Explore the impact of testosterone therapy, innovative medications for biomarker improvements, and a cautious approach to popular supplements. Matt shares his realistic philosophy on health optimization, avoiding risky behaviors, and nurturing relationships. It's all about tailored strategies for a healthier life!
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ADVICE

Consider Low‑Dose Lithium For Brain Health

  • Low‑dose lithium orotate (≈5 mg/day) is reasonable to consider for dementia risk based on water‑level studies and recent mechanistic work.
  • Matt started it after a Nature paper and clinical discussions, though he hasn't noticed subjective effects yet.
ADVICE

Use Creatine With Resistance Training

  • Take creatine (≈3–5 g/day) if you do resistance training to improve strength and body composition.
  • Matt uses 5 g/day and notes possible additional brain benefits though evidence is still emerging.
ADVICE

Prefer Few Proven Supplements And Verify Quality

  • Avoid piling on low‑evidence supplements; they cost money and raise risk of impurities and interactions.
  • Check third‑party testing (e.g., ConsumerLab) and favor brands with independent verification.
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