TMS for Treatment-Resistant Depression: A Clinical Guide with Dr. Owen Muir

In this episode of Psychiatry Boot Camp, Dr. Mark Mullen speaks with Dr. Owen Muir, psychiatrist, entrepreneur, and Chief Medical Officer of Radial Health, about the growing role of transcranial magnetic stimulation (TMS) in psychiatric treatment.
The discussion explores how TMS works as a form of noninvasive neuromodulation, using focused magnetic fields to influence neural circuits implicated in depression and other psychiatric conditions. Dr. Muir reviews the evidence supporting TMS for treatment-resistant depression, explains the FDA clearance pathway for neuromodulation devices, and discusses how stimulation parameters, coil positioning, and treatment protocols affect clinical outcomes.
The conversation also addresses the broader implications of neuromodulation in psychiatry, including emerging indications, technological innovation, and how clinicians can integrate TMS into modern psychiatric practice. This episode provides a practical and conceptual overview of one of the fastest-growing treatment modalities in mental health care.

Takeaways:

TMS is a noninvasive neuromodulation technique that uses magnetic fields to induce electrical activity in targeted cortical regions.
The primary FDA-cleared indication is treatment-resistant major depressive disorder, though research continues for other conditions including OCD and PTSD.
Treatment protocols depend on stimulation parameters, including frequency, location (often the dorsolateral prefrontal cortex), and session scheduling.
The FDA device clearance process differs from pharmaceutical approval, relying heavily on device equivalence and clinical safety data.
Neuromodulation represents a growing frontier in psychiatry, complementing pharmacotherapy and psychotherapy in the treatment of complex mood disorders.

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