The Joe Rogan Experience #1670 - David Sinclair
47 snips
Jun 18, 2021 
David Sinclair is a Harvard researcher and author of Lifespan, focusing on aging as a treatable disease. He discusses innovative methods for reversing aging, including epigenetic testing and hyperbaric oxygen therapy. Sinclair delves into the impacts of exercise and diet on longevity, advocating for practices like intermittent fasting. The conversation also covers the controversial drug metformin's potential benefits for health and aging. Sinclair emphasizes the importance of lifestyle choices and scientific communication in promoting long-term wellness.
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Reversing Aging with Injections
- A study showed that injecting metformin, growth hormone, and DHEA can reverse aging.
- This combination rejuvenated the thymus and reversed the biological clock by years.
Metformin and Hormesis
- Metformin inhibits mitochondria, but the body responds by making more.
- This process, called hormesis, increases energy and insulin sensitivity.
DNP and the FDA
- A chemical called DNP was sold as a weight loss drug in the 1920s.
- It caused overheating and some deaths, leading to the FDA Act and drug regulation.
