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Dr. Rhonda Patrick: Fasting, Creatine, Brain Performance & Longevity Breakthroughs | PBD #740

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Feb 17, 2026

Guest

Rhonda Patrick

Dr. Rhonda Patrick, biomedical scientist and longevity researcher, breaks down biological vs chronological aging and the latest AI-driven gene therapy and stem-cell advances. She discusses exercise reversing heart aging, creatine and fasting for brain performance, GLP-1 weight-drug debates, anxiety-reduction hacks, and ethical questions around gene editing.

02:22:32

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ADVICE

Lose Visceral Fat: Calories, Exercise, Or GLP‑1s

Reduce visceral fat by cutting calories and adding aerobic/HIIT; intermittent fasting is an effective tool.
GLP-1 receptor agonists also suppress appetite and slow gastric emptying but carry potential risks and require risk–benefit consideration.

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ANECDOTE

Childhood Jump Rope Team Shaped Her Fitness

Rhonda Patrick recounts being a competitive jump roper from age 8 to 16 and starting teams at schools.
She attributes early leadership, bone density benefits, and lifelong fitness habits to that experience.

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ADVICE

Supplement Creatine For Muscle And Brain

Take creatine monohydrate to saturate muscle (5 g/day) and increase brain uptake (10 g/day) for cognition and training gains.
Split doses and up to 20 g acutely can counter sleep-deprivation cognitive loss, per preliminary studies.

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Who is Dr. Rhonda Patrick and biological vs chronological age

03:12 • 2min

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AI, gene engineering and longevity breakthroughs

05:09 • 4min

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Reprogramming cells and partial rejuvenation research

08:47 • 4min

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Growing organs, stem cells and genetic 'tune-ups'

13:05 • 6min

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Ethics of gene editing and designer traits

18:44 • 11min

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Limits of biological-age tests and celebrity claims

30:06 • 3min

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Exercise program that reversed heart aging by 20 years

33:00 • 4min

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How sugar and visceral fat stiffen the heart

36:31 • 3min

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AI, shortcuts and public adoption of weight drugs

39:31 • 48sec

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GLP-1 drugs, obesity biology and practical approaches

40:19 • 13min

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Creatine for muscles and brain — dosing evidence

53:44 • 4min

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Creatine boosts cognition under stress and sleep loss

57:58 • 8min

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Chemotherapy's strengths, limits, and exercise oncology

01:06:24 • 6min

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Exercise intensity, VILPA bursts and disease risk reduction

01:12:42 • 9min

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Practical anxiety hacks: exercise, ketones, cold exposure

01:21:30 • 10min

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Happiness, marriage, kids and longevity

01:31:06 • 12min

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Mortality dwelling, purpose and prioritizing relationships

01:43:11 • 4min

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EMF concerns and the 49ers injury correlation

01:47:01 • 11min

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Overcoming negative upbringing and fostering resilience

01:58:17 • 10min

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Bilingualism, brain stimulation and Alzheimer's delay

02:08:19 • 3min

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Gut microbiome, postprandial inflammation and brain effects

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Patrick Bet-David sits down with Dr. Rhonda Patrick to break down biological vs. chronological aging, AI-driven gene therapy and stem-cell breakthroughs, creatine and fasting for brain performance, exercise’s role in reversing heart aging and lowering cancer risk, GLP-1 weight-loss debates, anxiety hacks, and the science behind longevity, family, and happiness.

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ABOUT US:

Patrick Bet-David is the founder and CEO of Valuetainment Media. He is the author of the #1 Wall Street Journal Bestseller “Your Next Five Moves” (Simon & Schuster) and a father of 2 boys and 2 girls. He currently resides in Ft. Lauderdale, Florida.

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