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Antibodies Redirect Immune System
- Antibodies serve as 'flags' that recognize cancer cells, enabling immune cells to be redirected.
- CAR T cells and T cell engaging biologics use antibodies to bridge and activate immune cells against tumors.
Target Identification Challenge
- While we have effective killing mechanisms in immunotherapy, finding precise cancer-specific targets remains a major challenge.
- Knowing which 'flag' to target on cancer cells is key for success and safety.
CD19 CAR T Side Effects Example
- CD19 CAR T therapies successfully target B cell cancers but sometimes attack brain cells causing side effects.
- This showcases the difficulty of exclusive cancer targeting in immunotherapies.