The Whisper Network

“The absolute worst part of my life”: Living with PMDD

7 snips
Mar 14, 2025
Jennifer Gordon, a Canada Research Chair focused on women’s mental health, joins the conversation on PMDD, a debilitating condition affecting many. She shares groundbreaking insights about its emotional toll and the historical context of PMDD research. The hosts candidly discuss their struggles with mood swings and search for effective treatments, including unconventional remedies like antihistamines. They emphasize the importance of awareness in tackling the stigma surrounding women's mental health and the urgent need for better medical support.
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INSIGHT

PMDD Is A Distinct Cyclical Mood Disorder

  • Dr. Jennifer Gordon defines PMDD as a mood disorder with an on-off pattern tied to the premenstrual phase.
  • She estimates 5–6% meet DSM criteria and up to ~10% have noticeable cyclical mood symptoms.
INSIGHT

PMDD Carries High Risk And Severe Mood Symptoms

  • PMDD differs from PMS by severity and risk; it includes intense mood symptoms and high suicidal ideation risk.
  • Dr. Gordon highlights mood symptoms like anger, irritability, and anxiety as core features.
ADVICE

Start With SSRIs Or Specific OCPs But Expect Limits

  • First-line treatments include SSRIs and drospirenone-containing oral contraceptives like Yaz, though effectiveness varies.
  • Dr. Gordon and hosts note many patients need additional or alternative strategies beyond these options.
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