Why does progesterone make some women feel calm and sleep deeply — while others feel anxious, depressed, or even suicidal?
In this powerful episode of Midlife Re-Alignment, Esther Blum is joined by board-certified OB-GYN Dr. Anat Sapan to unpack the truth about progesterone in perimenopause and menopause.
They break down:
- Why progesterone is the first hormone to decline in perimenopause
- The difference between progesterone and synthetic progestins
- Why some women experience progesterone intolerance
- Oral vs topical progesterone (and which helps sleep best)
- How progesterone affects anxiety, GABA, and allopregnanolone
- Whether topical progesterone protects the uterus
- The role of liver detox, receptor function, iodine, and endocrine disruptors
- Why progesterone may help breast tenderness, neuropathy, cholesterol, and even nervous system repair
If you’ve struggled with Prometrium side effects, 3AM wakeups, mood swings, or conflicting advice about hormone therapy — this episode will change the way you understand progesterone forever.
Connect with Dr. Anat:
https://doctoranat.com
Connect with Esther
Disclaimer: This podcast is for education only and is not medical advice.
The Midlife Realignment: Menopause, Hormones, HRT, Perimenopause, Weight Gain,Progesterone, Estrogen