The Evolving Wellness Podcast with Sarah Kleiner Wellness The Real Reason Hormone Replacement Works For Some + Not Others | Kashif Khan
Jun 25, 2025
Kashif Khan, an expert in genetics and personalized health, dives into the complexities of hormone replacement therapy. He shares why treatments can vary dramatically in effectiveness among individuals, particularly during perimenopause. The conversation highlights surprising environmental factors, like air fresheners, that can disrupt hormone balance. Kashif emphasizes the importance of understanding one's genetic makeup to tailor health approaches and offers insights into managing hormone-related challenges. Overall, this discussion inspires a more personalized view of wellness.
AI Snips
Chapters
Transcript
Episode notes
Support Estrogen Detox Pathways
- To personalize hormone treatment, monitor estrogen metabolism pathways and detoxification capacity to avoid inflammatory metabolites.
- Support detox pathways with supplements like DIM, I3C, and calcium D-glucarate to reduce hormone-related inflammation.
Ancient Genes in Modern Toxicity
- Modern environments expose us to hormone disruptors our ancient biology isn’t equipped to handle.
- Genes that once offered reproductive advantages can cause inflammation and disease in today's toxic world.
Test Genes Before Progesterone
- Do genetic testing before starting progesterone or any hormone therapy to predict metabolism and avoid unwanted side effects.
- Be cautious with dosage; some women convert progesterone to testosterone causing symptoms like hair loss and acne.