Rheumnow Podcast Turkey Tryptophan (11.28.2025)
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Nov 29, 2025 Dr. Jack Cush dives into intriguing topics like the resurgence of ranitidine and its journey back to H2 blockers. He explores data showing how fibromyalgia symptoms worsen in autumn and highlights a concerning link between gout and heart function. Cush also discusses the effectiveness of colchicine in reducing joint replacement risks. Finally, he shares insights on optimally managing biologic treatments for PsA in cases of TNFi failure. Tune in for the latest developments in rheumatology!
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Arthritis Major Cause Of Work Disability
- Arthritis is the leading cause of work limitations and disability in the U.S. and affects many outpatient visits.
- The 2023 NHIS found 38.8% of adults 18–64 with arthritis report work limitations, unchanged from four years prior.
Personal Take On L‑Tryptophan Return
- Jack Cush recounts L-tryptophan's removal in 1989 for eosinophil myalgia syndrome due to an impurity.
- He notes it returned to market in 2005 and shares his favorable personal experience using it for sleep.
Consider Colchicine To Reduce Joint Surgery
- Use colchicine to prevent recurrent gout flares and potentially reduce the need for joint replacement.
- The study of ~32,000 starters showed a 12% reduced overall joint replacement risk and 23% lower hip/knee replacement risk.