Mind & Matter MDMA, Microdosing LSD, THC & Memory, Human Psychopharmacology | Harriet de Wit | 96
Nov 15, 2022
Harriet de Wit, an experimental psychologist and professor at the University of Chicago, dives into the fascinating world of psychoactive drugs. She discusses MDMA's unique ability to alter emotional perception and enhance the pleasantness of social touch. Harriet also explores the intriguing effects of microdosing LSD, revealing its potential to boost vigor and reduce depression. Furthermore, she examines THC's impact on memory and offers insights into the clinical promise of MDMA for PTSD, emphasizing the importance of careful research and regulation.
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MDMA’s Social Effects Come From Serotonin
- MDMA acts more on serotonin than typical stimulants, producing distinct pro-social effects like increased feelings of loving and playfulness.
- These effects include reduced sensitivity to negative facial cues, which may ease social interaction and therapeutic vulnerability.
MDMA Blunts Detection Of Negative Faces
- MDMA raises the threshold for detecting anger and fear, so users literally 'don't see' negative expressions as easily.
- That perceptual change can explain both recreational social ease and therapeutic increased openness with therapists.
MDMA Enhances Social Touch Pleasantness
- MDMA increases perceived pleasantness of social touch in a dose-dependent way, an effect not produced by methamphetamine.
- This specificity helps explain why MDMA is uniquely described as enhancing tactile bonding.