Neurosalience

Neurosalience #S2E12 with Maurizio Corbetta - Attention, clinical use of neuroimaging, and a provocative theory for what resting state fMRI actually is

Dec 1, 2021
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ANECDOTE

Default Mode Network Found By Stacking PET Maps

  • Gordon Shulman's team discovered the default mode network by overlaying ~150 task PET maps and finding consistent negative responses at rest.
  • The serendipitous search for a single 'little man in the head' yielded a reproducible metabolic network active during rest.
ADVICE

Pre-Register Methods And Peer Critique Before Scanning

  • Rigorously pre-review experimental designs with diverse experts before data collection.
  • Corbetta describes weekly critiquing meetings at WashU where projects were vetted by leaders like Posner and Fox prior to scanning.
INSIGHT

Behavior And Brain Activity Collapse To Few Dimensions

  • Brain behavior relationships are low dimensional: many complex tasks reduce to a few latent components.
  • Corbetta cites visual and motor work where three components explain ~70% of variance across people and stimuli.
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