Neurology Exam Prep Podcast Episode 42 - Stroke in the Young
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Feb 17, 2022 Exploring stroke in young patients, topics include genetic features of catacil and carasil, cardiac causes of stroke, imaging in carotid dissections, Fabry's disease, vasculitis as a cause of stroke, and treatment challenges in young individuals.
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Interesting Cases Often Signal Complexity
- Dr. Jasne warns that cases that get everyone's attention are often the concerning or unusual ones.
- He values interdisciplinary discussion for these complex stroke cases.
Fabry Disease Presents Systemically
- Fabry disease is X-linked GLA mutation causing alpha-galactosidase A deficiency and cerebral small-vessel strokes.
- Look for neuropathic pain, angiokeratomas, hypohidrosis, corneal changes, renal and cardiac disease; treat with enzyme replacement.
MELAS Causes Stroke-Like Episodes
- MELAS causes stroke-like episodes that do not respect vascular territories and often show lactic acidosis.
- Suspect MELAS with short stature, exercise intolerance, seizures, elevated serum/CSF lactate, and confirm by muscle biopsy/genetics.