Extracellular Explorations—David Greening—Molecular Proteomics at the Baker Institute

As Head of Molecular Proteomics at the Baker Institute and Senior Research Fellow at La Trobe Institute for Molecular Science, David Greening brings a significant amount of insight to the podcast today, discussing the following:

• How proteomics can lead to a better understanding of the role of proteins in disease and health statuses, key regulators in biology, and what components might be found in extracellular vesicles (EVs)
• Whether EVs appear to be active or passive, and whether there might be some level of EV agency involved
• The promising field of imaging using fluorescently tagged proteins, vesicles, and RNA

Greening's molecular proteomics group focuses mainly on two areas: the study of extracellular vesicles, the components they contain, and the role they serve in cell communication and signaling, and proteomics, which is a field of study that looks at thousands of proteins in the body at a particular time, seeks to identify where they are located, and how they are expressed in states of health and disease.

Greening expounds on the many ways in which proteomics can advance our understanding of key regulators in biological processes, diseases such as cancer, what types of proteins are packaged in different EVs released by different cell types, and which components are secreted all at once from particular cells. He also discusses one of the main challenges in the field of proteomics, which is how to identify and analyze low expressed vesicle components.

When it comes to EVs and proteomics, Greenings is a wealth of knowledge. Tune in for all the details.

For more, visit https://www.baker.edu.au/research/laboratories/molecular-proteomics.