The Fellow on Call: The Heme/Onc Podcast Episode 143: Myeloma Series, Pt. 4 - Myeloma Pharmacology (2025)
Dec 30, 2025
Kathryn Maples, a clinical pharmacy specialist at Winship Cancer Institute, dives deep into myeloma pharmacology. She discusses the importance of triplet and quadruplet regimens and explains the intricacies of prescribing medications for myeloma treatment. Kathryn highlights side effects of key drugs like bortezomib and lenalidomide, and shares insights on managing toxicity and infection risks. Listeners will find her practical advice on supportive care and dosing strategies particularly eye-opening and valuable.
AI Snips
Chapters
Transcript
Episode notes
Pharmacist's Career Path And Dog Duke
- Kathryn Maples trained at University of Georgia, VCU, and spent time at Memorial Sloan Kettering before returning to Emory.
- She is obsessed with her German short-haired pointer dog named Duke and shares a lighthearted personal detail.
Tailor VTE Prophylaxis On IMiDs
- Assess VTE risk using IMPEDE/SAVED scores and history; escalate from aspirin to half-dose DOAC if prior clot or high risk.
- Consider apixaban 2.5 mg BID for immobility or significant additional risk factors.
Simplify Dexamethasone For Patients
- Simplify dexamethasone dosing and give it in clinic when possible to avoid patient confusion and home dosing errors.
- Split doses if patients have severe 'dexamethasone crash' but prefer giving 40 mg on days they attend infusion.