
Physics World Weekly Podcast Non-invasive pressure sensor could revolutionize how brain injuries are diagnosed
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Apr 10, 2025 Panicos Kyriacou, chief scientist at Crainio and professor of engineering, is pioneering a non-invasive optical sensor for measuring intracranial pressure, a critical factor in diagnosing brain injuries. He discusses the limitations of invasive methods and the urgent need for efficient, non-invasive alternatives. Kyriacou explains how the sensor uses light and machine learning to monitor blood flow in real-time, potentially revolutionizing brain injury assessments both in clinical settings and emergency situations.
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Light Reveals Pressure via Blood Flow
- Optical sensor measures blood flow changes caused by brain vessel compression due to pressure.
- Machine learning interprets these optical signals to estimate intracranial pressure non-invasively.
PPG Captures Blood Volume Changes
- Photoplethysmograph (PPG) captures blood volume changes in arteries during heartbeats.
- Brain pressure compression alters artery elasticity, modifying the PPG signal to reflect intracranial pressure changes.
From Research to Clinical Trials
- Cranio evolved from academic research to a startup with expert team and improved optical sensor technology.
- Current device is approved by UK's MHRA and undergoing new clinical trials with leading hospitals and collaborators.

