As MS Awareness Month continues, Selma Blair’s story underscores the resilience it takes to keep moving forward while living with multiple sclerosis. Blair, the actress known for Cruel Intentions, Legally Blonde and the Hellboy films, has become a leading voice in the MS community since publicly sharing her diagnosis in 2018. In this conversation from October 2025, Blair joins Hoda to discuss her lifelong health struggles, her relationship with her late mother, and the support she has found in her community, including from fellow stars Christina Applegate and Jamie-Lynn Sigler, who are navigating their own MS journeys.
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Making Space with Hoda Kotb