The Genius Life 5: Blueberries and Ketosis For A Better Brain | Robert Krikorian, PhD
Apr 13, 2018
In this discussion, Robert Krikorian, a leading researcher on cognitive aging, unlocks the secrets of diet's impact on brain health. He delves into the ketogenic diet, exploring how it can potentially enhance cognitive functions, especially for those facing mild cognitive impairment. Krikorian also highlights the power of blueberries, packed with anthocyanins, in reducing dementia risk and boosting memory. His insights weave together nutrition, lifestyle, and the science of aging, making a compelling case for dietary interventions in cognitive health.
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Ketosis Improved Memory Independent Of Weight Loss
- Ketogenic diets improved memory in six weeks in older adults with MCI, independent of weight loss or calorie reduction.
- Krikorian found reduced fasting glucose/insulin and memory gains correlated moderately with insulin decline, suggesting metabolic correction as a mechanism.
Small RCT Showed Weight Loss And Memory Gains
- Krikorian ran a randomized trial comparing a high‑carb 'healthy' diet to a 20 g/day ketogenic induction in older adults with MCI.
- The six‑week ketogenic arm lost ~15–16 lbs, reduced waist circumference, and improved memory performance.
Ketones May Reduce Alzheimer's Pathology
- Ketone metabolism may boost brain energy, reduce inflammation, and lower Alzheimer's pathology in animal studies.
- Krikorian cites reductions in beta amyloid and hyperphosphorylated tau in mice after ~8 weeks of ketosis as a potentially disease‑modifying pathway.