Tim Murray is pumped for a massive weekend of college football. Before bringing on Wes Reynolds and Brett Ciancia, Tim opens the podcast with the news of Oklahoma QB John Mateer's injury and Tim makes a pitch for a long shot Heisman bet.

Wes Reynolds joined Tim and recapped Indiana's 63-10 blowout win over Illinois. So, is Indiana -8 too big of a line move for the Hoosiers trip to Iowa this week? Other games discussed with Wes included...

Oregon at Penn St

Ohio State at Washington

UCLA at Northwestern

Texas A&M at Auburn

Florida St at Virginia

Lastly, Brett Ciancia of Pick Six Previews joined the podcast and discussed some trends regarding Penn State in "White Out" games as well as how teams in the Big Ten have fared traveling across time zones. Tim & Brett also chatted about the LSU at Ole Miss and Alabama at Georgia.

Check out Brett's Pick Six Plus at picksixpreviews.com/plus

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Week 5 Wednesdays with Wes Reynolds & Brett Ciancia (@PickSixPreviews)