Bloody Minded Episode 78 - All The Colours Of The Marrow | Overview of Myeloid Disorders
Feb 17, 2026
A lively birds-eye tour of the myeloid family of disorders using a seven-bucket framework. They map clonal haematopoiesis, precursor lesions and terminology like CHIP, CCUS and ICUS. Major groups covered include myeloproliferative neoplasms, myelodysplastic neoplasms and their overlaps, mastocytosis, acute myeloid leukaemia and rare histiocytic/dendritic disorders.
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Clonal Hematopoiesis Is Common With Age
- Clonal hematopoiesis represents mutated clones that may never become cancerous.
- Its prevalence rises with age and is often detected only via broad genetic sequencing panels.
Interpret Common CHIP Mutations Carefully
- Recognize DNMT3A, TET2 and ASXL1 as common CHIP genes when you see NGS results.
- Use a VAF cutoff around 2% to consider clonal hematopoiesis of indeterminate potential.
MPNs Are Overproduction Of Mostly Functional Cells
- Myeloproliferative neoplasms produce excess mature blood cells driven by activating tyrosine-kinase mutations.
- The cells are largely functional, so clinical features reflect overproduction rather than dysfunction.