LSD Part 1: History and Early Clinical Research | Neural Pharm Podcast

Jun 14, 2023

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From Basel, Switzerland to the summer of love in San Francisco. What did we learn about LSD, and why did it fall out of favor in the US? Part 2 will explore what's next in research...

Audio Correction: Colby misspoke 4:15: meant to say “Methergine is used for postpartum hemorrhage after delivery,” said “hemorrhage after bleeding” (which of course is redundant and a mistake).

Article on Ergotamine association with the Salem Witch Trials (from the Outside Hustle, Colby’s other blog):

Blotter Art examples:

https://keseyblotterart.com/

References:

Bryant C, Clark J. “How LSD Works.” Stuff You Should Know [podcast] 5 May 2016.

Dyck E. LSD: a new treatment emerging from the past. CMAJ. 2015 Aug 4;187(14):1079–80. doi: 10.1503/cmaj.141358. Epub ahead of print. PMID: 26243813; PMCID: PMC4592308.

Dyck, E. (2006). ‘Hitting Highs at Rock Bottom’: LSD Treatment for Alcoholism, 1950–1970. Soc. Hist. Med. 19: 313-329. [PDF]

Gasser, P. et al. (2014). Safety and Efficacy of Lysergic Acid Diethylamide-Assisted Psychotherapy for Anxiety Associated With Life-threatening Diseases. J. Nerv. Ment. Dis. 202: 513-520. [Full text]

Irwin, S. A., et al. (2013). Daily Oral Ketamine for the Treatment of Depression and Anxiety in Patients Receiving Hospice Care: A 28-Day Open-Label Proof-of-Concept Trial. J. Palliat. Med. 16: 958-965. [PDF]

Pollen M. “How to Change Your Mind: What the New Science of Psychedelics Teaches us About Consciousness, Dying, Addiction, Depression, and Transcendence.” Penguin Press. New York. 2018.

Sandison, R. A., et al. (1954). The therapeutic value of lysergic acid diethylamide in mental illness. J. Ment. Sci. 100: 491-507. [Summary]

Sandison, R. A. & Whitelaw, J. D. A. (1957). Further studies of the therapeutic value of lysergic acid diethylamide in mental illness. J. Ment. Sci. 103: 332-343. [Summary]

Sessa, B. (2008). Can psychedelic drugs play a role in palliative care? Eur. J. Pall. Care 15: 235-237. [PDF]

Simmons, J. Q., et al. (1966). Modification of Autistic Behavior with LSD-25. Am. J. Psych. 122: 1201-1211. [Summary]

Smart, R. G. & Storm, T. (1964). The Efficacy of LSD in the Treatment of Alcoholism. Quart. J. Alcohol 25: 333-338. [PDF]

Smith, C. M. (1958). A New Adjunct to the Treatment of Alcoholism: The Hallucinogenic Drugs. Quart. J. Alcohol 19: 406-417. [PDF]

Shroder T. “Apparently Useless: The Accidental Discovery of LSD. The Atlantic. 9 Sept 2014. Available at: https://www.theatlantic.com/health/archive/2014/09/the-accidental-discovery-of-lsd/379564/

Tanne, J. H. (2004). Humphrey Osmond. BMJ 328: 713. [Full text]

Vollenweider F. X. & Kometer, M. (2010). The neurobiology of psychedelic drugs: implications for the treatment of mood disorders. Nature Rev. Neurosci. 11: 642-651. [PDF]