Anesthesia and Critical Care Reviews and Commentary (ACCRAC) Podcast Episode 56: Bugs and Drugs Part 1 with Rachel Kruer
27 snips
Sep 28, 2017 Rachel Kruer, a clinical pharmacy specialist in surgical critical care at Johns Hopkins, dives deep into the world of antibiotics. She explains the difference between pharmacodynamics and pharmacokinetics, covering how various antibiotics work against common bacteria. The discussion includes critical topics like interpreting MICs for effective antibiotic selection, the role of rapid diagnostics, and options for those with penicillin allergies. Rachel also emphasizes the importance of local antibiograms to tailor treatment effectively.
AI Snips
Chapters
Transcript
Episode notes
Always Check The Local Antibiogram
- Consult your institution's antibiogram to guide empiric therapy and pick the best local agents.
- Aim for unit-specific antibiograms when available since resistance varies by unit.
Macrolides For Atypical Pathogens
- Macrolides inhibit protein synthesis and are useful for atypical coverage and COPD/pneumonia adjuncts.
- Azithromycin provides atypical and some strep coverage, not broad gram-negative cover.
Linezolid For Resistant Gram-Positives
- Use linezolid for MRSA or VRE when vancomycin or daptomycin aren't suitable and monitor platelets.
- Watch for serotonin syndrome risk with serotonergic drugs and thrombocytopenia with prolonged use.