TBPN

The Great Peptide Debate, SpaceX's Lunar Mass Driver, AI Coming for Zuck's Job | Martin Shkreli & Max Marchione, Mitchell Green, Shane Hegde, Dr. Adam Oskowitz, Robin Vince, David Senra

35 snips
Mar 23, 2026
Martin Shkreli, provocative former pharma executive, and Max Marchione, Superpower co-founder in health tech, clash over peptides, gray markets, and regulation. Mitchell Green, Lead Edge Capital investor, talks sticky software and venture bets. Shane Hegde, Air CEO building tools for creatives, explores AI for creative work. Robin Vince, BNY Mellon CEO, covers AI in banking. David Senra, Founders creator, talks builder mindset and AI disruption.
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ANECDOTE

Robin Vince Uses Eliza Before Client Meetings

  • Robin Vince already uses BNY Mellon's internal AI platform Eliza as a CEO copilot before client meetings.
  • He asks it for top talking points, and it synthesizes prior call reports, his last meeting, and recent news into suggested pitches.
INSIGHT

Tokenization Matters More In Logic Than In Wrapping

  • Robin Vince's view on tokenization was that merely putting an asset onchain changes little unless the underlying rules and workflows are also encoded.
  • He used bonds as the example: tokenizing the security matters less than embedding the indenture's 'if and therefore' logic onchain.
ANECDOTE

John Coogan Found The Right Show By Trying Formats

  • David Senra used John Coogan's pre-TBPN experiments as proof that action, not endless self-analysis, reveals the right path.
  • John Coogan tried multiple podcast formats, rejected ones that felt wrong, and only found conviction once the current live format clicked.
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