Your Longevity Blueprint 242: The Hormone Dysfunction Epidemic: What GLP-1 Drugs Reveal About Metabolic Health Part 2
I’m excited to have Ashley Koff, a registered dietitian with over 25 years of experience in functional and integrative nutrition, with me today for the second part of a two-part series.
In Part 1, we explained why your satiety hormones may be underperforming, what that means for aging and longevity, and what you can do today to optimize your metabolic health in a natural way.
In Part 2 today, we explore what your best shot for weight loss truly is, why people on GLP-1s lose hair, future options in the pipeline, and the problem with info-obesity.
Tips for Optimizing Your Satiety Hormones:
- Get a structured assessment of your weight, body composition, and bloodwork
- Ensure your meals are balanced
- Include a variety of fibers to support your gut bacteria and hormone production
- Pay attention to your meal timing and frequency
- Prepare meals that you genuinely enjoy to reinforce your satiety signaling and prevent cravings
Bio: Ashley Koff
Ashley Koff is a registered dietician and who is the founder of the Better Nutrition Program (BNP), the nutrition course director for UC Irvine’s Susan Samueli Integrative Health Institute’s Integrative and Functional Medicine Fellowship, and a faculty member at the Integrative and Functional Nutrition Academy (IFNA), where she teaches “An Integrative and Functional Nutrition Approach to Obesity and Weight Management.”
She is also the author of the upcoming book Your Best Shot (HarperOne, Jan. 6, 2026). A practitioner for more than 25 years, Koff is leading a transformative movement in personalized nutrition, turning “better, not perfect” choices into practical, sustainable strategies that deliver real health outcomes. Through patient stories and personal experience, she shows that optimal health is not just possible — it’s essential to living your fullest life. Koff has been recognized as one of CNN’s Top 100 Health Makers, featured in InStyle as “Hollywood’s Leading Dietitian,” and selected as Westin’s global nutrition ambassador.
In this episode:
- A five-part assessment to uncover whether your satiety hormone activity is suppressed, delayed, or dysfunctional
- How weight and digestion are part of a larger ecosystem that impacts your entire health span
- How GLP-1 agonists can create stress within the body
- The differences between biosimilar and non-peptide GLP-1 medications, and what that means for your body
- How meal timing and frequency, macronutrient balance, and varied flavors support hormone signaling and satiety
- How “infobesity” creates confusion in midlife, making personalized nutrition essential
- Why you need to assess your own body, rather than following generic rules
Links and Resources:
Guest Social Media Links:
Ashley Koff on Instagram
Relative Links for This Show:
📘 Free Guide: Precision Hormone Therapy
Download Dr. Stephanie Gray’s comprehensive guide to bioidentical hormone therapy.
👉 Visit: https://ihhclinic.com/
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Your Longevity Blueprint 5HTP – 90 capsules
Calocurb Clinical — Appetite & Craving Support
A practitioner-exclusive, plant-based supplement designed to enhance your body’s natural fullness signals (GLP-1 and PYY), helping reduce cravings and calorie intake. Available only through clinics such as the Integrative Health and Hormone Clinic. Visit us or order here: https://ihhclinic.com/
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