TBPN Something Mini is Coming, Anthropic's $20B Round, Ackman’s Meta Move | Bryan Johnson, Andrew Huberman, Matthew Zeitlin, Joon Sung Park, David Risher, Todd McKinnon, Alexander Ksendzovsky
Guest
Andrew Huberman
Guest
Todd McKinnon
Guest
David Risher
Guest
Joon Sung Park
Guest
Matthew Zeitlin
Guest
Bryan Johnson
Andrew Huberman, neuroscientist and science communicator, briefs on sleep, caffeine, peptides, and wellness. Todd McKinnon, Okta CEO, explains identity and security for AI agents. David Risher, Lyft CEO, covers growth, Waymo partnership, and autonomous rollouts. Joon Sung Park, Simile CEO, describes human-behavior simulations for enterprises. Matthew Zeitlin, energy reporter, examines data centers’ grid impact. Bryan Johnson, entrepreneur, outlines his Blueprint longevity regimen.
03:37:58
Simulating People Scales Market Testing
- Simile simulates individual and population behavior to let companies test product, pricing, and messaging before launch.
- High-fidelity agent models can predict likely questions and reactions at scale for Fortune 500 customers.
Model The Irrational Half Of Decisions
- Simile focuses on modeling the irrational, value-driven half of human decisions, not superhuman reasoning.
- Aligning data collection with product needs creates an immediate path to commercial insight.
Use Simulations To Trace 'Why'
- Use simulations to trace causal chains and audit why people made certain choices.
- Leverage that interpretability to design better policies and products before deployment.
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Intro
00:00 • 6min
John Palmer's 'Get a Mac Mini' AI Essay
06:23 • 7min
Anthropic's Massive Funding Round
13:30 • 5min
Anthropic's Energy & Grid Commitments
18:18 • 2min
Ad break
20:06 • 28sec
Anthropic Growth Charts and Political Spend
20:34 • 5min
X/Meta Timeline Reactions & Marketplace Anecdotes
25:28 • 3min
Warner Bros, Netflix & Paramount Bidding Drama
28:44 • 4min
Higgsfield Controversy and Creator Backlash
32:31 • 6min
Video Tools, Nano Banana, and Creative Workflows
38:35 • 3min
Ad break
41:51 • 16sec
Ackman's $2B Meta Bet and Market Views
42:07 • 6min
Ad break
48:07 • 19sec
Luxottica–Meta Ray-Bans Sales Surge
48:25 • 6min
Higgsfield, IP Risks, and Industry Response
54:14 • 5min
Transition to Guest Interviews
59:38 • 4min
Bryan Johnson: Olive Oil Routine & Blueprint
01:03:43 • 5min
Inside Immortals: Million-Dollar Personalized Health
01:08:15 • 4min
Data, AI & Physical Interventions in Blueprint
01:12:40 • 6min
Peptides, FDA, and Evidence Caution
01:18:42 • 4min
Blueprint Scaling: Free Tools to Premium Immortals
01:23:08 • 10min
Matthew Zeitlin: Data Centers' Rising Energy Demand
01:33:24 • 3min
Where Data Centers Locate and Price Effects
01:36:11 • 6min
Hyperscalers' Grid Payments and Community Pushback
01:42:15 • 5min
Short-term Power Solutions & Environmental Tradeoffs
01:47:27 • 6min
Energy Supply Constraints vs. AI Demand
01:53:32 • 8min
Transition to Lightning Round Guests
02:01:57 • 2min
Joon Sung Park: Simile's Human Behavior Simulations
02:03:38 • 6min
Simile Use Cases: CVS, Gallup, Earnings Calls
02:09:50 • 4min
Simile's Moat: Modeling Irrational Human Behavior
02:14:01 • 1min
David Risher: Lyft Growth, Profits, and Strategy
02:15:07 • 7min
Waymo Partnership and Nashville Rollout
02:21:52 • 10min
Todd McKinnon: Okta's Identity in AI Era
02:31:58 • 9min
Identity Needs for Millions of Agents
02:40:36 • 7min
Alexander Ksendzovsky: Biological Computing Overview
02:47:40 • 7min
Biological Compute: Products, Adapters, and Partnerships
02:54:25 • 46sec
Andrew Huberman: Sleep, Caffeine, Peptides, and Wellness
02:55:11 • 10min
Peptides, Retatrutide, and Safety Warnings
03:04:56 • 12min
Cannabis, Addiction, and Social Media Effects
03:16:53 • 15min
Final Notes, News Wrap, and Model Updates
03:31:58 • 5min
Outro
03:37:17 • 35sec
#1404
• Mentioned in 29 episodes
Blind Spots
When Medicine Gets It Wrong, and What It Means for Our Health
Marty Makary, MD
In 'Blind Spots', Dr. Marty Makary explores the latest research on critical topics ranging from the microbiome to childbirth, nutrition, and longevity, revealing the biggest blind spots of modern medicine.
The book tackles urgent yet unsung issues in the $4.
5 trillion health care ecosystem, highlighting how medical dogma and lack of evidence-based practices have led to significant public health crises, such as the opioid epidemic, peanut allergy epidemic, and mismanagement of hormone replacement therapy.
Makary argues for a return to sound scientific studies and evidence-based medicine to improve health care outcomes.
#112
• Mentioned in 161 episodes
Dopamine Nation
Finding Balance in the Age of Indulgence
Anna Lembke, MD
In 'Dopamine Nation,' Dr. Anna Lembke delves into the scientific discoveries that explain why overindulgence in high-reward, high-dopamine stimuli leads to pain.
The book combines personal narratives from her clinical practice with the latest psychology research to illustrate how to find contentment and connectedness by keeping dopamine in check.
Lembke discusses the impact of modern addictions, such as those related to smartphones, food, and other behaviors, and provides strategies for managing consumption and transforming lives.
The book emphasizes the importance of balancing the science of desire with the wisdom of recovery.
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- (02:05) - Something Mini is Coming
- (10:28) - Anthropic's $20B Round
- (20:11) - 𝕏 Timeline Reactions
- (28:51) - Where the WB Deal Stands Now
- (36:44) - Higgsfield Accused of Ragebait
- (49:20) - Ackman’s Meta Move
- (01:03:54) - Bryan Johnson, a tech entrepreneur and founder of Braintree, is dedicated to extending human lifespan through his "Blueprint" protocol, which includes consuming three tablespoons of high-polyphenol extra virgin olive oil daily, accounting for 15% of his caloric intake. In the conversation, he discusses the health benefits of this regimen, emphasizing the importance of specific types of olive oil for longevity, and introduces his "Immortals" program—a comprehensive, data-driven health initiative designed to optimize biological age through personalized protocols and advanced monitoring.
- (01:34:01) - Matthew Zeitlin, a correspondent at Heatmap News, discusses the significant energy demands of data centers, noting that large facilities can consume as much electricity as entire cities. He highlights the challenges utilities face in meeting this demand, including the need for substantial infrastructure upgrades and the potential impact on electricity prices. Zeitlin also addresses the environmental concerns associated with data centers, such as increased emissions and water usage, and emphasizes the importance of balancing technological advancement with sustainable energy practices.
- (02:03:14) - Joon Sung Park, co-founder and CEO of Simile, discusses the company's development of a foundational model of human behavior capable of simulating society at both individual and population levels to predict outcomes. He highlights applications such as enabling Fortune 500 companies to interact with agents representing real people, allowing for more accurate market predictions and decision-making. Park also emphasizes the potential of these simulations to model entire markets or nations, aiming to enhance policy and product development through a deeper understanding of societal dynamics.
- (02:15:15) - David Risher, CEO of Lyft and co-founder of Worldreader, discusses the company's record bookings and profits, attributing this success to a strong focus on customer satisfaction. He highlights Lyft's strategic initiatives, including international expansion and the integration of autonomous vehicles, particularly through a partnership with Waymo in Nashville. Risher also addresses the challenges posed by market volatility and emphasizes the importance of maintaining a clear focus on data and long-term goals amidst fluctuating stock prices.
- (02:31:41) - Todd McKinnon, co-founder and CEO of Okta, discusses his journey from leading engineering at Salesforce to founding Okta in 2009, aiming to address identity management challenges in the emerging cloud computing era. He highlights the company's growth to a $3 billion annual revenue with 6,000 employees, emphasizing the increasing importance of identity management amid trends like AI and remote work. McKinnon also shares insights on the surge of interest in AI agents across industries, stressing the need for secure implementation and the evolving role of software engineers in a rapidly expanding software landscape.
- (02:47:11) - Alexander Ksendzovsky, a neurosurgeon and neuroscientist, has been cultivating neurons on electrodes for two decades. He discusses leveraging the superior energy efficiency and adaptability of biological neurons to enhance artificial neural networks, aiming to address the energy challenges in AI computing. Ksendzovsky emphasizes that this approach is not science fiction but a current, deployable technology, with his company actively integrating biological networks to improve AI model performance and efficiency.
- (02:55:15) - Andrew Huberman is an American neuroscientist and tenured professor of neurobiology at Stanford University School of Medicine, where he studies brain function, behavior, and visual system plasticity. He is the creator and host of the Huberman Lab podcast, which translates neuroscience and health research into practical tools for sleep, focus, fitness, and mental health. Huberman is known for bringing academic research to a broad audience through long-form interviews and solo deep dives on science-backed protocols.
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