TWiV 1252: Clinical update with Dr. Daniel Griffin
Sep 13, 2025
This week, Dr. Griffin dives into a Legionnaires’ outbreak in Harlem and the emergence of the invasive longhorned tick. The discussion also touches on a potential Ebola outbreak in the Congo. Florida's decision to end childhood vaccine mandates raises eyebrows amid rising measles cases. The conversation then shifts to COVID-19, highlighting effective treatments like Paxlovid and the importance of vaccination. Long COVID research is gaining traction, with new clinical studies underway and a push for answers and support for affected individuals.
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question_answer ANECDOTE
Personal Dog Story About Daisy
Daniel Griffin shares a personal dog story about naming his daughter Daisy after his dog Zara, which his wife resisted.
He uses this to explain his fondness for golden retrievers during the episode.
insights INSIGHT
SARS-CoV-2 Spillover Into Household Dogs
High seroprevalence (68%) occurred in dogs living with SARS-CoV-2 infected humans, showing frequent spillover.
Overall canine seroprevalence was 12.24%, indicating household exposure drives transmission to pets.
insights INSIGHT
Pfizer LP.8 Shows Strong Interim Immune Response
Pfizer reported robust neutralizing responses to its LP.8 2025-26 adapted monovalent vaccine in interim phase 3 data.
Early results showed at least fourfold antibody rises with no safety signals in high-risk adult cohorts.
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In his weekly clinical update, Dr. Griffin with Vincent Racaniello discuss the continued Legionnaire’s outbreak in Harlem, invasive Asia longhorned tick and associated disease, potential Ebola outbreak in the Congo, Florida ending childhood vaccine mandates, before Dr. Griffin deep dives into recent statistics on the measles epidemic, RSV, influenza and SARS-CoV-2 infections, the Wasterwater Scan dashboard, Johns Hopkins measles tracker, SARS-CoV-2 spillover into household/domestic dogs, real data demonstrating the benefits of COVID-19 vaccines, states that increase access to COVID-19 vaccines, effective and availability to PAXLOVID, where to find PEMGARDA, long COVID treatment center, where to go for answers to your long COVID questions, the beginning of numerous long COVID clinical studies and contacting your federal government representative to stop the assault on science and biomedical research.
Adverse events associated with childhood vaccines: evidence bearing on causality (NLM)
Measles Vaccination: Know the Facts (ISDA: Infectious Diseases Society of America)
Deaths following vaccination: what does the evidence show (Vaccine)
Influenza: Waste water scan for 11 pathogens (WastewaterSCan)
Influenza-Associated Hospitalizations During a High Severity Season — Influenza Hospitalization Surveillance Network, United States, 2024–25 Influenza Season (CDC: MMWR)
US respiratory virus activity (CDC Respiratory Illnesses)
Economic Analysis of Protein Subunit and mRNA RSV Vaccination in Adults aged 50-59 Years (CDC: ACIP)
Evidence to Recommendations Framework (EtR): RSV Vaccination in Adults Aged 50–59 years (CDC: National Center for Immunization and Respiratory Diseases)
Waste water scan for 11 pathogens (WastewaterSCan)
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