S4:E5 Unlocking the Dark Genome for Lupus and Other Autoimmune Diseases

Autoimmune diseases like lupus impact over 5 million patients globally, but treatment options remain limited. Now, decoding the once mysterious "dark genome" could bring new therapies. Over 90% of our DNA was once considered "junk"—but we’ve learned this dark matter regulates gene expression and human disease. This episode takes you to the pioneers who are unlocking the dark genome's potential to correct root causes of complex conditions like lupus. We'll chat with those illuminating this uncharted territory and developing novel approaches. 

Guests include:

• Rosana Kapeller, M.D., Ph.D., Co-Founder, President, & CEO at Rome Therapeutics
• Steve Kafka, General Partner at S32
• Keri Mastrogiacomo, mother of a Lupus patient
• Katherine Cavanagh, Associate Investment Director at Cambridge Associates 

This episode has named a Winner by the International Women’s Podcast Awards for their “A Moment of Visionary Leadership” category.

Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company. Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world.

Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include discretionary and advisory portfolio management, staff extension, and alternative asset class mandates.