Stuff You Should Know How Antidepressants Work
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Mar 13, 2025 Discover how antidepressants like SSRIs and tricyclics tackle depression, despite the mystery behind their mechanisms. Explore the history and evolution of these medications and their surprising origins. Learn about innovative treatments like psychedelics and nutraceuticals, alongside the necessary dietary precautions when using MAOIs. Hear engaging discussions on personal experiences with depression, alongside the complexities of treatment options and new mental health challenges emerging today.
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Tricyclic Antidepressants and Side Effects
- Tricyclic antidepressants, introduced in the 1950s and 60s, also work on serotonin reuptake.
- However, they aren't selective, leading to a wider range of side effects.
SNRIs and Their Effectiveness
- SNRIs block reuptake of both serotonin and norepinephrine.
- Despite targeting two neurotransmitters, they're no more effective than SSRIs.
MAOIs and the Cheese Reaction
- MAOIs prevent the breakdown of tyramine, which regulates blood pressure.
- This can lead to the "cheese reaction," a hypertensive crisis triggered by certain foods.
