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Short Course Dual Antiplatelet
- Consider short-term dual antiplatelet therapy for high-risk TIA or mild stroke (early weeks).
- Typical practice uses 3–4 weeks for maximal early secondary prevention benefit.
Statin Targets After Stroke
- Start high-intensity statin after ischemic stroke (atorvastatin or rosuvastatin).
- Aim for LDL <70 if multiple vascular risk factors, and <100 if non-atherosclerotic stroke with few risks.
Nonstatin LDL-Lowering Options
- Use ezetimibe or PCSK9 inhibitors when statins are insufficient or not tolerated.
- Expect PCSK9 monoclonal antibodies to be effective but costly and require prior approval.


