The Metabolic Link

Health Optimization Medicine: HBOT, Nervous System Regulation, and Mitochondrial Healing | The Metabolic Link Ep. 82 | Dr. Scott Sherr|

Dec 2, 2025
In this engaging discussion, Dr. Scott Sherr, a board-certified internal medicine physician and leader in Integrative Hyperbaric Medicine, delves into the transformative power of hyperbaric oxygen therapy (HBOT). He recounts a life-changing moment witnessing HBOT's dramatic impact on a trauma patient. Topics include the importance of pre-treatment optimization, the sympathetic spiral of doom, and innovative strategies to enhance mitochondrial health. Dr. Sherr envisions a future where HBOT integrates seamlessly with personalized metabolic support for improved healing and human performance.
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INSIGHT

Oxygen Is A Controlled Stressor

  • HBOT floods the body with oxygen and creates reactive oxygen species that drive epigenetic shifts, stem cell release, and angiogenesis.
  • Patients need antioxidant and metabolic capacity to handle that oxidative load or they may worsen after treatment.
ADVICE

Prepare Patients Before Intensive HBOT

  • Optimize patients metabolically before intensive HBOT and often wait about three months to build resilience.
  • Use metabolomics, nutrient repletion, and nervous system regulation to improve HBOT outcomes.
INSIGHT

Metabolomics Over Genetics For Action

  • Metabolomics gives a real-time window into cellular function and environmental impacts, better than genetics alone.
  • Sherr uses metabolomics to guide nutrient, toxin, and mitochondrial interventions in his Health Optimization Medicine framework.
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