The mindbodygreen Podcast 614: The science behind NAD, longevity, & metabolic health | Andrew Salzman, M.D.
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Sep 7, 2025 
Andrew Salzman, M.D., a physician and biomedical entrepreneur, dives deep into the world of NAD, highlighting its critical role in metabolic health and aging. He explains when NAD levels decline and how to assess them. The conversation covers the powerful connection between NAD and menopause, lifestyle impacts, and the benefits of NMN supplements. Salzman also shares insights on safe dosages, supports for NAD enhancement, and emerging research that promises to reshape our understanding of health and longevity in the coming years.
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Real-World Improvements Reported
- A 45-year-old tennis player regained court play after two months of using the product following arthritis-related downtime.
- A woman with vascular dementia improved puzzle performance after two to three months of supplementation.
Closing The Drain Matters As Much As Filling
- NAD levels are controlled by both production and breakdown; stopping breakdown is as important as supplying precursors.
- CD38 is the major enzyme that breaks down NAD and increases with age and inflammation.
CD38 Drives Age-Related NAD Loss
- CD38 rises with age (about double by 40–50) and directly cleaves NAD, driving tissue NAD loss.
- Removing CD38 in animals preserves ovarian NAD and delays menopause-like decline.
