Freely Filtered, a NephJC Podcast Freely Filtered 065: BEST Fluids
Feb 10, 2024
Podcast covers topics like the impact of balanced crystalloids vs saline in kidney transplants, outcomes of fluid resuscitation trials, autoimmune protocol diet, and Michael Collins (the astronaut). Also, discussions on BEST Fluids, delayed graft function, and Hawthorne Effect.
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From Systematic Review To Landmark Trial
- Michael Collins recounted progressing from a systematic-review prompt to launching a large trial across Australia and New Zealand.
- He credited collaboration, trial network support, and eight to nine years of effort to reach publication.
Don’t Exclude Children By Default
- Include children in trials unless strong safety or scientific reasons exclude them.
- This builds evidence for pediatric practice instead of defaulting to adult-only data.
Switching To A Clearer Primary Outcome
- The original ranked composite primary outcome was changed, blinded, to a binary DGF outcome after blinded interim event-rate checks.
- Changing to a simpler, clinician-understandable outcome improved interpretability and maintained trial rigor.