Freely Filtered, a NephJC Podcast

Freely Filtered 055: STOP ACE!

Jan 29, 2023
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INSIGHT

eGFR Equations Converge At Low GFR

  • Using different eGFR equations at low GFR makes little difference; all are imprecise below ~20 mL/min.
  • STOP-ACE tested multiple equations and found consistent results.
INSIGHT

Massive Screening, Narrow Enrollment

  • STOP-ACE screened ~17,000 patients to randomize 411, showing strict selection for eligibility.
  • Many excluded patients reflected necessary rigor but limit generalizability.
INSIGHT

STOP-ACE Patient Profile

  • Baseline STOP-ACE population had median age 63 and median eGFR ~18, with 29% <15 mL/min.
  • Only ~15% were non-white, highlighting demographic limits.
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