Boost Your Biology with Lucas Aoun 148. A Real Life Limitless Drug To Enhance Intelligence? TAK-653 & More Explained By Sir Sadalot
9 snips
Mar 28, 2023 AI Snips
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Agmatine Cured Early Depression
- Sir Sadalot tried agmatine for his depression and felt relief within an hour of a 1 g dose.
- That experience converted him to exploring novel nootropics and developing targeted compounds.
Polyamine Site Shifts NMDA Balance
- Agmatine antagonizes the NMDA polyamine site and shifts NMDA expression toward synaptic (neuroprotective) sites.
- Higher spermidine and lower agmatine associate with suicide in postmortem studies.
TAK‑653: A Selective AMPA PAM
- TAK-653 is a selective AMPA positive allosteric modulator (PAM) developed as an antidepressant with cognitive benefits.
- Studies in healthy people showed improved verbal fluency and executive function with good safety.