Count to 10 - Anaesthetic Primary Podcast EP33 – Intro to Pharmacokinetics | Anaesthetic Primary Topic | General Pharmacology | CT10
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Feb 22, 2025 Dive deep into pharmacokinetics as key topics unfold! Discover the ADME structure—absorption, distribution, metabolism, and elimination. Learn how different routes of drug administration affect bioavailability and the significance of first-pass metabolism. Explore how compartment modeling aids in understanding drug distribution. Ani also breaks down metabolic reactions and the factors that can modify metabolism. Get insights on half-life concepts and what influences recovery time after infusion. An engaging listen for all pharmacology enthusiasts!
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IM Backup For Pediatric Access
- Arnie recalls using IM injections as paediatric backup when IV access fails, showing practical utility.
- He links IM reliability to local blood flow variability and onset unpredictability.
Elimination Versus Excretion Defined
- Elimination removes drug from plasma (distribution + metabolism); excretion removes drug from body (urine, bile, lung).
- Distinguish elimination vs excretion when interpreting PK results.
Plan For Renal Excretion Mechanisms
- Expect renal excretion for small (<30,000 Da), water-soluble, unbound drugs via filtration, secretion or distal diffusion.
- Use agents like probenecid to block proximal tubular secretion and prolong drug plasma time when needed.