Retrograde signalling: cannabinoids act backwards

Dr. Matt Hill is one of the world’s leading cannabis neuroscientists, former president of the International Cannabinoid Research Society, and a researcher with over 21,000 citations studying how the endocannabinoid system regulates the brain and body.Cannabis affects different people in completely opposite ways — calming one person while causing crippling anxiety in another — and Hill explains why the biology makes this inevitable, why both sides of the cannabis debate are getting it wrong, and why legalisation in Canada accidentally destroyed the very research that could have answered our biggest questions.Expect to learn why CB1 is the most widely distributed receptor in the brain yet almost nobody has heard of it, how endocannabinoids work backwards across the synapse unlike any other signalling system, why low-dose THC calms the amygdala but high-dose THC causes paranoia and anxiety, why women get higher than men on the same dose of cannabis due to a liver enzyme difference, why only a third of people genuinely benefit from medical cannabis while a third get nothing, how cannabis triggers schizophrenia in genetically vulnerable people without actually causing the disease, why Canadian legalisation killed cannabis clinical trials through a bureaucratic GMP-versus-GPP standoff, what the real cardiovascular risks of chronic cannabis use are, why cannabis users paradoxically have lower obesity rates, and much more…Timestamps: 00:00 Trailer02:00 Dr. Matt Hill — Cannabis Neuroscientist02:25 The Endocannabinoid System: Your Body’s Own Cannabis04:23 Every Biological Function It Controls06:30 The Most Distributed Receptor Nobody’s Heard Of07:20 Why Cannabis Science Is So Politically Toxic09:35 Both Sides Are Wrong: The Three Blind Men Problem10:23 The Frustrating Polarity of the Cannabis Debate12:37 Your Personal Experience Doesn’t Generalise16:25 Why Cannabis Feels Like a Different Drug for Different People17:52 Retrograde Signalling: How Cannabis Works Backwards20:08 Low Dose Calms, High Dose Causes Paranoia — Here’s Why22:24 Women Produce More 11-Hydroxy-THC Than Men25:52 Why Receptor Distribution Makes Cannabis Unpredictable27:11 The PET Scan Problem: Why We Can’t Map Your Receptors29:04 Why Cannabis Companies Don’t Fund Real Research31:25 How Legalisation Accidentally Killed Cannabis Science34:46 The GMP vs GPP Bureaucratic Disaster38:09 David Nutt: Drug Policy Driven by Politics Not Science43:01 Why You Can’t Standardise Cannabis Dosing Like Alcohol49:44 The Three Thirds Rule: Benefit, Side Effects, or Nothing53:05 The Best Evidence: Where Cannabis Actually Works53:36 Schizophrenia Risk — It’s a Trigger, Not a Cause55:52 Cardiovascular Risk: The Under-Discussed Real Danger57:02 Does Exercise Cancel Out Cannabis Heart Risk?58:14 The Obesity Paradox: Why Cannabis Users Are Thinner01:01:03 Chronic Pain, MS, Epilepsy and PTSD — The Medical Evidence01:03:18 Final Thoughts and a Plea for Billionaire Stoners...Email for sponsorship enquiries: evan@thegiantsshoulder.com ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/