Mechanism: SSRIs reduce platelet serotonin

In this episode, we explore a critical drug interaction: SSRIs combined with anticoagulants increase major bleeding risk by 35-47%. Should age and sex change our prescribing decisions? We break down the evidence from nearly 100,000 patients and discuss safer antidepressant alternatives for high-risk individuals.

Faculty: Paul Zarkowski, M.D. Host: Richard Seeber, M.D.

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• Earn 0.75 CME: Quick Take Vol. 77
• Do SSRIs Increase Major Bleeding Risk with Oral Anticoagulants?