In this episode, Layne Norton, PhD, dissects the landmark 2025 systematic review & meta-analysis in Advances in Nutrition: "The Effects of Aspartame on Glucose, Insulin, and Appetite-Regulating Hormone Responses in Humans". (PMID: 40381807)
This episode is perfect if you've heard claims like "diet soda spikes insulin," "artificial sweeteners cause diabetes," or "aspartame is toxic" — Layne uses this gold-standard review to separate science from fear-mongering.
If you're into evidence-based nutrition, skeptical of viral health scares, or just want to know if your Diet Coke habit is secretly wrecking your metabolism — this episode has the receipts.
Subscribe for more deep-dive breakdowns of the latest research, and drop a comment: Do you use aspartame? Has this changed your view?
SPONSORS
• Outwork Nutrition - Evidence-Based Supplements to Support Your Hard Work: https://outworknutrition.com
• David Protein - Buy 4 cartons, get 1 FREE at: https://davidprotein.com/pages/layne
LAYNE'S COMPANIES
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Outwork Nutrition: https://outworknutrition.com
REPS Research Review: https://biolayne.com/reps
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TIMESTAMPS
0:00:00 - Intro
0:02:53 - What is Aspartame
0:05:15 - Health Claims
0:11:26 - How Aspartame is Metabolized
0:14:15 - HRCTs
0:15:56 - Outwork Nutrition
0:18:06 - Study Overview
0:19:25 - Inclusion Criteria
0:31:43 - Results
0:40:38 - David Protein
0:42:13 - Results Cont.
0:49:51 - Discussion
0:58:53 - Conclusion
SHOW NOTES
https://biolayne.com/podcasts/dr-layne-norton-podcast/study-deep-dive-does-aspartame-increase-insulin-episode-20
