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Expert Insight on New Data From SGO 2023 Informing Treatment for Endometrial, Cervical, and Ovarian Cancers

Decera Clinical Education Oncology Podcast

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The Safety and Tolerability of Pembrolyzumab in ChemoRT

Patients received three cycles of pembrolyzumab similar to the prior study I talked about we didn't have a priming of the IL. We were not able to see a difference in CD8 T cells to T regulatory cell ratio either in tissue or in blood between the two arms. This in part was probably due to the fact that there was significant patient variability. However, we did see different patterns of change in E7 peptide in peripheral blood if Pempalizumab was given during chemoradiation. So that was really interesting. Both sequences altered multiple immune cell populations and we're doing further work in that area.

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