In this episode, we talk to Professor Wenbiao Gan from the Neuroscience and Physiology and Skirball Institute at New York University School of Medicine.
Professor Gan tells us about how he started to become interested in studying sleep and its impact on learning and memory.
He talks about intriguing and hands-on ways to assess the formation and elimination of dendritic spines in the mouse cortex, and how different experimental tasks like running backwards on a treadmill influence spine formation with or without sleep. Some counterintuitive results are presented and Professor Gan also shares his perspective on the synaptic homeostasis hypothesis.
In the end, Professor Gan gives some thoughts about the future of sleep research and suggests new methods of improvement in the area.
If you would like to find out more, here is a link to Professor Gan's full list of publications:
Links to the studies mentioned in the podcast:
Glossary of terms
- (synaptic) pruning = a natural phase in the development of the nervous system during which connections between neurons that are no longer needed die off
- dendrites = tree-like extensions of the neuron
- dendritic spines = extensions of a dendrite that help receive information from other neurons
- synaptic homeostasis = the idea that neural synapses cannot keep strengthening forever. Instead, they must also downscale at some point in order to make space for further strengthening. Such downscaling can be done in a relative manner that preserves information coded by the synapses in question.
Episode produced by Bianca Strete and Sophie Smith
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