253. Dr. Jessica Shepherd: On Menopause, HRT, and Longevity Tips for Women
The Ultimate Human with Gary Brecka
Timing HRT for longevity and heart health
Jessica explains optimal HRT timing (late perimenopause/early menopause, ~45–55) to protect heart, brain, bone, and inflammation.
Most women spend years dismissing their own symptoms: brain fog, frozen shoulder, mood crashes, vanishing libido, never realizing these aren’t signs of aging, they’re signals of a hormonal shift that begins nearly a decade before menopause hits. Today, I’m with board-certified OB-GYN and menopause expert Dr. Jessica Shepherd to dismantle the myths that have kept millions of women unnecessarily suffering, including the misrepresented WHI study that put hormone therapy off the table for a generation.
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Timestamps
00:00 Intro of Show
04:20 Dr. Jessica Shepherd’s Background
08:03 Perimenopause: Earlier Than You Think
11:35 Early Signs of Menopause
15:24 Dutch Test and Hormone Replacement Therapy
24:06 Ideal Timeframe for Hormone Therapy
26:33 The Invisible Hormone Disruptors
27:23 The Caregiver Syndrome
28:35 Why Autoimmune Disease Targets Women
30:40 What Does a Healthy Immune System Look Like?
34:38 Blood Sugar Monitoring: HbA1c and CGM
41:50 How to Strengthen Women’s Immune System
47:42 Black Maternal Mortality and Systemic Health Gaps
57:23 Dr. Shepherd’s Message to the Administration
58:43 Role of AI in Healthcare
1:01:40 Generation M: The Book Every Woman Needs
1:03:39 Weight Training as a Longevity Non-Negotiable
1:06:10 Dr. Shepherd’s Morning Routine
1:08:13 Creatine for Muscle and Brain Health
1:12:28 Real-World Recovery: Movement, Nutrition, and Supplements
1:17:14 Connect with Dr. Shepherd
1:21:01 What does it mean to you to be an Ultimate Human?
Disclaimer: This podcast is for informational purposes only and does not provide medical advice. It is not intended for diagnosing or treating any health condition. Always consult a licensed healthcare professional before making health or wellness decisions.
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