Evaluating models with wet-lab validation

Priscilla explains the feedback loop: model hypotheses, wet-lab tests, and iterative improvement to validate predictions.

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Episode notes

This crossover episode from the Latent Space podcast features Mark Zuckerberg and Priscilla Chan on the 10-year anniversary of the Chan Zuckerberg Initiative and their expanded Biohub vision. They discuss how a “Frontier Biology Lab” working in sync with a “Frontier AI Lab” could enable breakthroughs like a Virtual Cell and true N-of-1 precision medicine. The conversation covers the acquisition of Evolutionary Scale and ESM3, new biological data collection at scale, and how AI-powered biology might transform drug discovery and disease prevention.

Sponsors:

Blitzy:

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Framer:

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Serval:

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Tasklet:

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Claude

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CHAPTERS:

(00:00) About the Episode

(04:27) CZI origins and focus

(08:29) Why tools over cures

(14:43) Virtual cells and imaging (Part 1)

(20:19) Sponsors: Blitzy | Framer

(23:24) Virtual cells and imaging (Part 2)

(25:22) Data diversity and grounding

(32:30) Evaluating models and Biohub (Part 1)

(37:53) Sponsors: Serval | Tasklet

(40:42) Evaluating models and Biohub (Part 2)

(41:06) Future healthcare and aging