PCOS, Large Egg Yield, and Targeting Insulin Resistance

Welcome back to Ask the Egg Whisperer! I'm so excited to have Dr. Steven Palter join me on today's episode. Dr. Palter is the medical and scientific director at Gold Coast IVF in Woodbury, New York, and an internationally recognized leader in fertility treatment. He's also the creator of the PCOS to Pregnancy Protocol - the first comprehensive remote system targeting the root causes of PCOS and the Palter Fertility Method, a personalized approach to diagnosis and care that integrates metabolic health, surgical precision, and emerging reproductive technologies.

Watch the full conversation (with more live chatted questions) on Dr. Aimee's Instagram Live.

In this episode, we tackle real questions from our community (women ranging from 36 to 47), dealing with everything from diminished ovarian reserve and repeated IVF failure to PCOS, endometriosis, and experimental treatments like mitochondrial replacement therapy. Dr. Palter and I don't always agree, and that's what makes this conversation so valuable. We get into the nuances of DHEA and testosterone supplementation, when genetic testing is worth it even with limited embryos, why your stimulation protocol might be the problem, and how targeting insulin resistance can transform outcomes for PCOS patients.

In this episode, we cover:

• Why AMH predicts egg quantity, not quality and why that distinction matters
• The truth about DHEA and testosterone priming, including a major new study showing no benefit
• Mitochondrial replacement therapy (three-parent IVF): promise, limitations, and what the data actually shows
• Fresh vs. frozen transfers with diminished ovarian reserve, and why PGTA testing is still valuable
• The #1 reason for immature eggs and no blasts and the protocol fix that works 80% of the time
• Endometriosis, BCL6 testing, and when suppression vs. surgery makes sense
• How targeting insulin resistance and inflammation in PCOS patients is changing outcomes dramatically

Resources:

• Dr. Steven Palter's practice: Gold Coast IVF — goldcoastivf.com
• PCOS to Pregnancy Protocol by Dr. Palter
• Previous podcast episode with Dr. Palter on the Palter Fertility Method
• Dr. Aimee's fertility supplement stack

Would you like to learn more about IVF?Click here to join Dr. Aimee for The IVF Class. The next live class call is on Monday, April 20, 2026 at 4pm PST, where Dr. Aimee will explain IVF and there will be time to ask her your questions live on Zoom. Subscribe to my YouTube channel for more fertility tips! Join Egg Whisperer School Subscribe to the newsletter to get updates Dr. Aimee Eyvazzadeh is one of America's most well known fertility doctors. Her success rate at baby-making is what gives future parents hope when all hope is lost. She pioneered the TUSHY Method and BALLS Method to decrease your time to pregnancy. Learn more about the TUSHY Method and find a wealth of fertility resources at www.draimee.org. Keywords fertility, IVF, egg quality, AMH, diminished ovarian reserve, DHEA, testosterone priming, PCOS, insulin resistance, mitochondrial replacement therapy, three-parent IVF, PGTA, PGT-A, genetic testing, embryo testing, endometriosis, BCL6, frozen embryo transfer, fresh transfer, egg maturity, dual trigger, ovarian PRP, progesterone support, IVF protocol, fertility doctor, reproductive endocrinology, Ask the Egg Whisperer, Dr. Aimee, Dr. Steven Palter, Gold Coast IVF, fertility supplements, CoQ10, NAD, rapamycin, hydrosalpinx, IVF failure, recurrent implantation failure, translocation, modified natural cycle